Cryoablation of bone metastases in thyroid and adrenocortical cancers

This study looked at a minimally invasive treatment called cryoablation, which uses extreme cold to destroy cancer that has spread to the bones, in people with thyroid (including MTC) or adrenocortical cancer. Seventeen patients with painful bone metastases were treated using advanced CT guidance, and all procedures were technically successful. Most patients experienced rapid and meaningful pain relief—often within just one week—with pain levels continuing to improve over time and a reduced need for strong pain medications. Importantly, the treatment was generally very safe, with no life-threatening side effects, and most patients did not need surgery or additional treatments afterward. Overall, the findings show that cryoablation can be a safe and effective option to reduce pain, improve quality of life, and help people stay active while living with advanced endocrine cancers.

Ref: de Freitas, R. M. C., Hoff, A. O., Fragoso, M. C. B. V., Sousa, A. M., Danilovic, D. L. S., de Castroneves, L. A., Grigio, T. R., Tsunemi, M. H., Buchpiguel, C. A., & Caldas, J. G. M. P. (2026). Cryoablation of bone metastases in thyroid and adrenocortical cancers. Endocrine-Related Cancer, 33(1), Article e250306, e250306. Retrieved Feb 4, 2026, from https://doi.org/10.1530/ERC-25-0306
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